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Buy Now Secure transaction. Your transaction is secure. The Liverwort that most people are interested in is Radula marginata. This product is an extract of Hepatica americana. Please make sure you are purchasing the proper 'Liverwort' extract. 11 people found this helpful. Perrottetinene is a naturally occurring cannabinoid compound found in liverworts from the genus Radula native to Japan, New Zealand and Costa Rica, namely Radula perrottetii, Radula marginata and Radula laxiramea, along with a number of similar compounds. We offer the best exotic ethnobotanicals and psychoactive herbs such as Kratom, Kava Kava, Blue Lotus, and much more in resins, extracts, seeds, and tinctures.
Several hundred million years ago mosses and their kin went one way, evolutionarily speaking, and the lineage of trees and flowering plants went the other. Somehow, in the vast expanse of geologic time that followed, a few members of these distantly related groups in the plant kingdom copied one another in making something of great interest to humans: the psychoactive chemical, or cannabinoid, that gets people high.
The recent discovery of another source of a cannabinoid comes from a plant that is a relative of the mosses called liverwort. One genus of the plant, Radula, boasts a handful of species that produce a chemical that is a lot like tetrahydrocannabinol (THC) from Cannabis sativa, or marijuana.
Why a liverwort, which lives and reproduces quite differently from a plant like Cannabis, would make this molecule remains a mystery. What we now know, however, is the cannabinoid from liverwort and the one in Cannabis are almost exactly the same and have quite similar effects in the mammalian brain.
The Radula compound has been dubbed perrottetinene, or PET, after Radula perrottetii, one of the few liverwort species that makes it. Although researchers first described perrottetinene in 1994, how it compared with THC in structure and activity in mammalian brains did not become clear until now.
In what may be the only chemical synthesis paper ever to thank incense sellers in its acknowledgments, Jürg Gertsch of the University of Bern and colleagues confirmed the properties of PET that make it similar to THC. Publishing October 24 in Science Advances, the researchers show through a variety of tests that PET from these Radula species looks and acts a lot like THC from Cannabis. “Curiosity-driven research can lead to interesting results,” says Daniele Piomelli, professor of anatomy and neurobiology at the University of California, Irvine, who was not involved in the study. “This is solid work, very credible, showing that this type of liverwort contains compounds that are akin both in structure and pharmaceutical activity to psychoactive cannabinoids in the cannabis plant.”
To establish this strong similarity, the investigators synthesized forms of PET based on the naturally occurring compound. Using cell preparations, the research team checked to see if the PET molecules bound to the same brain receptors in the cell membrane as THC—and they do. They also checked to see if the PETs bound brain proteins that THC doesn’t—they don’t.
Turmeric and black peppper for inflation no sugar. Moms went away when she went in the “Candida diet” after months she had no pain or inflammation, don’t doubt Candida albicans, starts as a single cell yeast and grows threads and connects togeather through your cells and becomes more like mycelium. Radula marginata is a species of plant in genus Radula, a genus of liverworts. It is native to New Zealand. It has been found to contain perrottetinene and perrottetinenic acid. The private property we harvest this from is small in size so larger orders can not be fulfilled.
The team then examined how PET and THC compare in potency, and found PET to be less potent. They also discovered THC-like effects when PET was administered to mice—the animals responded similarly to both treatments, including moving more slowly and having lower body temperatures.
When the researchers evaluated the effects of PET compared with THC on inflammation pathways in mouse brains, they finally found a difference. Although PET’s psychoactive effects were less potent, it reduced certain molecules associated with inflammation, says study author Michael Schafroth, currently a postdoctoral researcher at The Scripps Research Institute.
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In contrast, THC did not tamp down levels of these inflammation-related molecules, called prostaglandins. “These prostaglandins are involved in many processes (such as) memory loss, neuroinflammation, hair loss and vasoconstriction,” he says. That means PET is “highly interesting for medicinal applications, as we can expect fewer adverse effects while still having pharmacologically important effects.” The reduced potency of PET also might put a damper on any interest in the liverwort for recreational use, especially in an era of increasingly loosened cannabis regulation.
Radula samples were available from the incense sellers the authors thanked in their acknowledgments. But scattered online descriptions from people who have tried it to get high suggest limited success. And because liverworts reproduce without using seeds, “the cultivation and reproduction of Radula species containing the cannabinoid might be challenging,” Gertsch says. The pharmaceutical promise of liverwort could mean a higher profile for the modest moss and its kin, known collectively as bryophytes. “To date, bryophytes are a bit neglected in terms of bio-prospecting,” he notes, referring to the search for organisms that might have medicinal value. “I think this is a great example that liverworts can generate natural products of relevance to humans.”
It may already have been relevant to the people who live where these species of Radula occur naturally, which are as far afield as Japan, New Zealand and Costa Rica. There are hints that the Maori people of New Zealand use it as an herbal medicine, although not necessarily for its THC-like properties. Gertsch adds, however, that no serious ethnobotanical or ethnopharmacological research confirms such uses.
With a synthetic means to make this compound now established, the next step will be to investigate it in animal models of inflammatory diseases such as multiple sclerosis, Gertsch says, directly comparing it with the activity of THC.
Radula Marginata
Radula Marginata is a rare species of the Radulaceae family found in New Zealand. It is a moss that creates the same effect as marijuana. This moss-like plant is most commonly known as Liverwort. It has been a popular interest of most researchers and scientists. Many think that Radula Marginata has medicinal characteristics that can cure many serious ailments.
The composition of Radula Marginata is such that it has the same effects as the complex ingredient tetrahydrocannabinol (THC) present in Cannabis Sativa. These compounds can regulate how a person feels and reacts. This plant got significant attention among scientists when Jurg Gertsch wrote about it in the famous journal, Science Advances.
![Perrottetii Perrottetii](/uploads/1/1/9/8/119848067/972578233.jpg)
Effects of the plant
As professionals are inclined to study the nature of the plant further, scientists have established that Radula Marginata can be used as an oil to cure pain caused due to muscle strain and glaucoma. Its effects show a possibility for recovering appetite in many people.
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It contains a substance called ‘perrottetinene’ which acts as an anti-inflammatory painkiller for the body. It has a lesser psychoanalytic effect, which helps in easing anxiety. It is a better alternative against steroids. This means that it has a natural pain-absorbent.
Studies are yet to find any consequences of using Radula Marginata. Theorists have estimated that this plant will become a best-seller for medicinal purposes. The soothing and calm smell of this moss hints that it will be of great interest and value for incense manufacturers. It is legal in most countries.
Ethnic significance
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Radula Marginata is found in the northern part of New Zealand. The roots of this moss might be used by the native population for lowering body temperature and for recreational purposes. Only social media is proof of this usage as people from New Zealand have discussed it on their accounts.
It is said that Maori people used Wairuakohu, a traditional name for Radula Marginata because they believed that the moss cured ailments related to digestion and liver. Scientists have yet to say anything about this.
In reality, the ethnic importance of this plant cannot be stated clearly due to a lack of information. The mention of this fungi-like plant goes back to 1994 when a Japanese researcher described this plant’s properties.
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Conclusion
People harvest this plant in the wild environment. Its dried form is used for making herbal products such as incense and liquid extract. The harvest of this product is ethically and legally allowed with no particular restraints. The most common solvents for this plant are alcohol and glycerin.
Many have contested the economic importance of this plant. It has even been dismissed as a non-beneficial entity for human consumption. However, 2018 onwards, the craze for this plant has escalated as companies demand to use it for scents, medicines, etc.
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One thing is clear– Radula Marginata is going to set up a new history for medical uses once researchers have assessed all its properties and molecular characteristics. Till then, use it as an incense to enjoy its calming scent.